Cytoplasmic RNA Sensor Pathways and Nitazoxanide Broadly Inhibit Intracellular Mycobacterium tuberculosis Growth

To establish stable infection, Mycobacterium tuberculosis (MTb) must overcome host innate immune mechanisms, including those that sense pathogen-derived nucleic acids. Here, we show that the host cytosolic RNA sensing molecules RIG-I-like receptor (RLR) signaling proteins RIG-I and MDA5, their commo...

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Pubblicato in:iScience
Autori principali: Ranjbar, Shahin, Haridas, Viraga, Nambu, Aya, Jasenosky, Luke D., Sadhukhan, Supriya, Ebert, Thomas S., Hornung, Veit, Cassell, Gail H., Falvo, James V., Goldfeld, Anne E.
Natura: Artigo
Lingua:Inglês
Pubblicazione: Elsevier 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6909047/
https://ncbi.nlm.nih.gov/pubmed/31805434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.isci.2019.11.001
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