Transcriptomic Dissection of Hepatocyte Heterogeneity: Linking Ploidy, Zonation, and Stem/Progenitor Cell Characteristics

BACKGROUND & AIMS: There is a long-standing debate regarding the biological significance of polyploidy in hepatocytes. Recent studies have provided increasing evidence that hepatocytes with different ploidy statuses behave differently in a context-dependent manner (eg, susceptibility to oncogene...

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Veröffentlicht in:Cell Mol Gastroenterol Hepatol
Hauptverfasser: Katsuda, Takeshi, Hosaka, Kazunori, Matsuzaki, Juntaro, Usuba, Wataru, Prieto-Vila, Marta, Yamaguchi, Tomoko, Tsuchiya, Atsunori, Terai, Shuji, Ochiya, Takahiro
Format: Artigo
Sprache:Inglês
Veröffentlicht: Elsevier 2019
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Original Research
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6909008/
https://ncbi.nlm.nih.gov/pubmed/31493546
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.jcmgh.2019.08.011
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