The Modified Surface Killing Assay Distinguishes between Protective and Nonprotective Antibodies to PspA

Pneumococcal surface protein A (PspA) elicits antibody protective against lethal challenge by Streptococcus pneumoniae and is a candidate noncapsular antigen for inclusion in vaccines. Evaluation of immunity to PspA in human trials would be greatly facilitated by an in vitro functional assay able to...

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Publicado en:mSphere
Autores principales: Genschmer, Kristopher R., Vadesilho, Cintia F. M., McDaniel, Larry S., Park, Sang-Sang, Hale, Yvette, Miyaji, Eliane N., Briles, David E.
Formato: Artigo
Lenguaje:Inglês
Publicado: American Society for Microbiology 2019
Materias:
Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6908419/
https://ncbi.nlm.nih.gov/pubmed/31826968
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1128/mSphere.00589-19
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