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Defects in interferon pathways as potential biomarkers of sensitivity to oncolytic viruses

Increased sensitivity of cancer cells to viruses is a prerequisite for the success of oncolytic virotherapy. One of the major causes of such a phenotype is the disruption of innate antiviral defenses associated with dysfunction of type 1 interferons (IFNs) that permits unlimited replication of virus...

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Bibliographic Details
Published in:Rev Med Virol
Main Authors: Matveeva, Olga V., Chumakov, Peter M.
Format: Artigo
Language:Inglês
Published: John Wiley and Sons Inc. 2018
Subjects:
Online Access:https://ncbi.nlm.nih.gov/pmc/articles/PMC6906582/
https://ncbi.nlm.nih.gov/pubmed/30209859
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/rmv.2008
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