Peroxynitrite Activated Drug Conjugate Systems Based on a Coumarin Scaffold Toward the Application of Theranostics

Two novel drug-conjugates based on a “coumarin linker” have been designed for the synergic release of a therapeutic agent and fluorescent probe for the potential application of theranostics. The drug conjugates; CC-RNS and CI-RNS were designed to be activated by reactive oxygen species or reactive n...

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Publicado en:Front Chem
Autores principales: Odyniec, Maria L., Han, Hai-Hao, Gardiner, Jordan E., Sedgwick, Adam C., He, Xiao-Peng, Bull, Steven D., James, Tony D.
Formato: Artigo
Lenguaje:Inglês
Publicado: Frontiers Media S.A. 2019
Materias:
Chemistry
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6906548/
https://ncbi.nlm.nih.gov/pubmed/31867305
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fchem.2019.00775
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