The autophagy receptor p62/SQST-1 promotes proteostasis and longevity in C. elegans by inducing autophagy

Autophagy can degrade cargos with the help of selective autophagy receptors such as p62/SQSTM1, which facilitates the degradation of ubiquitinated cargo. While the process of autophagy has been linked to aging, the impact of selective autophagy in lifespan regulation remains unclear. We have recentl...

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Publicat a:Nat Commun
Autors principals: Kumsta, Caroline, Chang, Jessica T., Lee, Reina, Tan, Ee Phie, Yang, Yongzhi, Loureiro, Rute, Choy, Elizabeth H., Lim, Shaun H. Y., Saez, Isabel, Springhorn, Alexander, Hoppe, Thorsten, Vilchez, David, Hansen, Malene
Format: Artigo
Idioma:Inglês
Publicat: Nature Publishing Group UK 2019
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Article
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6906454/
https://ncbi.nlm.nih.gov/pubmed/31827090
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13540-4
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