Inactivation of Interferon Regulatory Factor 1 Causes Susceptibility to Colitis-Associated Colorectal Cancer

The mechanisms linking chronic inflammation of the gut (IBD) and increased colorectal cancer susceptibility are poorly understood. IBD risk is influenced by genetic factors, including the IBD5 locus (human 5q31), that harbors the IRF1 gene. A cause-to-effect relationship between chronic inflammation...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Jeyakumar, Thiviya, Fodil, Nassima, Van Der Kraak, Lauren, Meunier, Charles, Cayrol, Romain, McGregor, Kevin, Langlais, David, Greenwood, Celia M. T., Beauchemin, Nicole, Gros, Philippe
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6906452/
https://ncbi.nlm.nih.gov/pubmed/31827213
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55378-2
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