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The fitness cost of mismatch repair mutators in Saccharomyces cerevisiae: partitioning the mutational load

Mutational load is the depression in a population’s mean fitness that results from the continual influx of deleterious mutations. Here, we directly estimate the mutational load in a population of haploid Saccharomyces cerevisiae that are deficient for mismatch repair. We partition the load in haploi...

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Détails bibliographiques
Publié dans:Heredity (Edinb)
Auteurs principaux: Galeota-Sprung, Benjamin, Guindon, Breanna, Sniegowski, Paul
Format: Artigo
Langue:Inglês
Publié: Springer International Publishing 2019
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Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6906417/
https://ncbi.nlm.nih.gov/pubmed/31515531
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41437-019-0267-2
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