Clinical Implications of Sub-grouping HER2 Positive Tumors by Amplicon Structure and Co-amplified Genes

ERBB2 amplification is a prognostic marker for aggressive tumors and a predictive marker for prolonged survival following treatment with HER2 inhibitors. We attempt to sub-group HER2+ tumors based on amplicon structures and co-amplified genes. We examined five HER2+ cell lines, three HER2+ xenograph...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Maoz, Myriam, Devir, Michal, Inbar, Michal, Inbar-Daniel, Ziva, Sherill-Rofe, Dana, Bloch, Idit, Meir, Karen, Edelman, David, Azzam, Salah, Nechushtan, Hovav, Maimon, Ofra, Uziely, Beatrice, Kadouri, Luna, Sonnenblick, Amir, Eden, Amir, Peretz, Tamar, Zick, Aviad
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6906288/
https://ncbi.nlm.nih.gov/pubmed/31827209
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55455-6
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