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m(6)A minimally impacts the structure, dynamics, and Rev ARM binding properties of HIV-1 RRE stem IIB

N(6)-methyladenosine (m(6)A) is a ubiquitous RNA post-transcriptional modification found in coding as well as non-coding RNAs. m(6)A has also been found in viral RNAs where it is proposed to modulate host-pathogen interactions. Two m(6)A sites have been reported in the HIV-1 Rev response element (RR...

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Detalhes bibliográficos
Publicado no:PLoS One
Main Authors: Chu, Chia-Chieh, Liu, Bei, Plangger, Raphael, Kreutz, Christoph, Al-Hashimi, Hashim M.
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6905585/
https://ncbi.nlm.nih.gov/pubmed/31825959
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0224850
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