Induction of miR 21 impairs the anti-Leishmania response through inhibition of IL-12 in canine splenic leukocytes

Visceral Leishmaniasis is a chronic zoonosis and, if left untreated, can be fatal. Infected dogs have decreased cellular immunity (Th1) and develop a potent humoral response (Th2), which is not effective for elimination of the protozoan. Immune response can be modulated by microRNAs (miRNAs), howeve...

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Vydáno v:PLoS One
Hlavní autoři: Melo, Larissa Martins, Bragato, Jaqueline Poleto, Venturin, Gabriela Lovizutto, Rebech, Gabriela Torres, Costa, Sidnei Ferro, Garcia, Leandro Encarnação, Lopes, Flávia Lombardi, Eugênio, Flávia de Rezende, Patto dos Santos, Paulo Sérgio, de Lima, Valéria Marçal Felix
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
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Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6905561/
https://ncbi.nlm.nih.gov/pubmed/31825987
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0226192
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