The MAPT H1 Haplotype Is a Risk Factor for Alzheimer’s Disease in APOE ε4 Non-carriers

An ancestral inversion of 900 kb on chromosome 17q21, which includes the microtubule-associated protein tau (MAPT) gene, defines two haplotype clades in Caucasians (H1 and H2). The H1 haplotype has been linked inconsistently with AD. In a previous study, we showed that an SNP tagging this haplotype...

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Bibliografski detalji
Izdano u:Front Aging Neurosci
Glavni autori: Sánchez-Juan, Pascual, Moreno, Sonia, de Rojas, Itziar, Hernández, Isabel, Valero, Sergi, Alegret, Montse, Montrreal, Laura, García González, Pablo, Lage, Carmen, López-García, Sara, Rodrííguez-Rodríguez, Eloy, Orellana, Adelina, Tárraga, Lluís, Boada, Mercè, Ruiz, Agustín
Format: Artigo
Jezik:Inglês
Izdano: Frontiers Media S.A. 2019
Teme:
Neuroscience
Online pristup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6905227/
https://ncbi.nlm.nih.gov/pubmed/31866851
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fnagi.2019.00327
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