Alterations in Polyamine Metabolism in Patients With Lymphangioleiomyomatosis and Tuberous Sclerosis Complex 2-Deficient Cells

BACKGROUND: Lymphangioleiomyomatosis (LAM), a destructive lung disease that affects primarily women, is caused by loss-of-function mutations in TSC1 or TSC2, leading to hyperactivation of mechanistic/mammalian target of rapamycin complex 1 (mTORC1). Rapamycin (sirolimus) treatment suppresses mTORC1...

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Опубликовано в: :Chest
Главные авторы: Tang, Yan, El-Chemaly, Souheil, Taveira-Dasilva, Angelo, Goldberg, Hilary J., Bagwe, Shefali, Rosas, Ivan O., Moss, Joel, Priolo, Carmen, Henske, Elizabeth P.
Формат: Artigo
Язык:Inglês
Опубликовано: American College of Chest Physicians 2019
Предметы:
Diffuse Lung Disease
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6904859/
https://ncbi.nlm.nih.gov/pubmed/31299246
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.chest.2019.05.038
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