Sensory innervation in porous endplates by Netrin-1 from osteoclasts mediates PGE2-induced spinal hypersensitivity in mice

Spinal pain is a major clinical problem, however, its origins and underlying mechanisms remain unclear. Here we report that in mice, osteoclasts induce sensory innervation in the porous endplates which contributes to spinal hypersensitivity in mice. Sensory innervation of the porous areas of sclerot...

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Udgivet i:Nat Commun
Main Authors: Ni, Shuangfei, Ling, Zemin, Wang, Xiao, Cao, Yong, Wu, Tianding, Deng, Ruoxian, Crane, Janet L., Skolasky, Richard, Demehri, Shadpour, Zhen, Gehua, Jain, Amit, Wu, Panfeng, Pan, Dayu, Hu, Bo, Lyu, Xiao, Li, Yusheng, Chen, Hao, Qi, Huabin, Guan, Yun, Dong, Xinzhong, Wan, Mei, Zou, Xuenong, Lu, Hongbin, Hu, Jianzhong, Cao, Xu
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6904550/
https://ncbi.nlm.nih.gov/pubmed/31822662
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13476-9
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