CD19 and CD70 Dual-Target Chimeric Antigen Receptor T-Cell Therapy for the Treatment of Relapsed and Refractory Primary Central Nervous System Diffuse Large B-Cell Lymphoma

Background: The therapeutic efficacy of chimeric antigen receptor (CAR) T-cells targeting CD19 has been illustrated in the treatment of diffuse large B-cell lymphoma (DLBCL). However, there is a 21–35% relapse rate after anti-CD19 CAR T-cell induced remission. In addition, CAR T-cell therapy has sev...

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Detalhes bibliográficos
Publicado no:Front Oncol
Main Authors: Tu, Sanfang, Zhou, Xuan, Guo, Zhenling, Huang, Rui, Yue, Chunyan, He, Yanjie, Li, Meifang, Chen, Yiran, Liu, YuChen, Chang, Lung-ji, Li, Yuhua
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Oncology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6904344/
https://ncbi.nlm.nih.gov/pubmed/31867275
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fonc.2019.01350
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