Optimizing sgRNA length to improve target specificity and efficiency for the GGTA1 gene using the CRISPR/Cas9 gene editing system

The CRISPR/Cas9 gene editing system has enhanced the development of genetically engineered animals for use in xenotransplantation. Potential limitations to the CRISPR/Cas9 system impacting the development of genetically engineered cells and animals include the creation of off-target mutations. We so...

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Udgivet i:PLoS One
Main Authors: Matson, Anders W., Hosny, Nora, Swanson, Zachary A., Hering, Bernhard J., Burlak, Christopher
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science 2019
Fag:
Research Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6903732/
https://ncbi.nlm.nih.gov/pubmed/31821359
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0226107
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