CMET-33. PHASE II STUDY OF PALBOCICLIB IN BRAIN METASTASES HARBORING CDK PATHWAY ALTERATIONS

BACKGROUND: Up to 25% of all cancer patients will develop brain metastases and prognosis remains poor. In preclinical work, we discovered that more than 50% brain metastases genomically diverge from primary tumors and harbor alterations in genes involved with cell cycle regulation. We thus initiated...

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Detalhes bibliográficos
Publicado no:Neuro Oncol
Main Authors: Brastianos, Priscilla, Cohen, Justine, Wang, Nancy, Lee, Eudocia, Ligibel, Jennifer, Chukwueke, Ugonma, Keeley, Maura, Oh, Kevin, White, Michael, Gerstner, Elizabeth, Batchelor, Tracy, Lawrence, Donald, Ryan, David P, John Iafrate, A, Giobbie-Hurder, Anita, Flaherty, Keith, Santagata, Sandro, Carter, Scott, Cahill, Daniel, Sullivan, Ryan
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
Assuntos:
CNS Metastasis
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6902907/
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/neuonc/noz175.234
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