m(6)A mRNA methylation initiated by METTL3 directly promotes YAP translation and increases YAP activity by regulating the MALAT1-miR-1914-3p-YAP axis to induce NSCLC drug resistance and metastasis

BACKGROUND: METTL3 is an RNA methyltransferase that mediates m(6)A modification and is implicated in mRNA biogenesis, decay, and translation. However, the biomechanism through which METTL3 regulates MALAT1-miR-1914-3p-YAP axis activity to induce NSCLC drug resistance and metastasis is not very clear...

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Shranjeno v:
Bibliografske podrobnosti
izdano v:J Hematol Oncol
Main Authors: Jin, Dan, Guo, Jiwei, Wu, Yan, Du, Jing, Yang, Lijuan, Wang, Xiaohong, Di, Weihua, Hu, Baoguang, An, Jiajia, Kong, Lingqun, Pan, Lei, Su, Guoming
Format: Artigo
Jezik:Inglês
Izdano: BioMed Central 2019
Teme:
Research
Online dostop:https://ncbi.nlm.nih.gov/pmc/articles/PMC6902496/
https://ncbi.nlm.nih.gov/pubmed/31818312
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-019-0830-6
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