Overexpressed ITGA2 promotes malignant tumor aggression by up-regulating PD-L1 expression through the activation of the STAT3 signaling pathway

BACKGROUND: Recent studies have reported that Integrin alpha 2 (ITGA2) plays an essential role in tumor cell proliferation, invasion, metastasis, and angiogenesis. An abnormally expressed ITGA2 correlates with unfavorable prognoses in multiple types of cancer. However, the specific mechanism of how...

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Tallennettuna:
Bibliografiset tiedot
Julkaisussa:J Exp Clin Cancer Res
Päätekijät: Ren, Dianyun, Zhao, Jingyuan, Sun, Yan, Li, Dan, Meng, Zibo, Wang, Bo, Fan, Ping, Liu, Zhiqiang, Jin, Xin, Wu, Heshui
Aineistotyyppi: Artigo
Kieli:Inglês
Julkaistu: BioMed Central 2019
Aiheet:
Research
Linkit:https://ncbi.nlm.nih.gov/pmc/articles/PMC6902401/
https://ncbi.nlm.nih.gov/pubmed/31818309
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13046-019-1496-1
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