The Synergistic Use of IL-15 and IL-21 for the Generation of NK Cells From CD3/CD19-Depleted Grafts Improves Their ex vivo Expansion and Cytotoxic Potential Against Neuroblastoma: Perspective for Optimized Immunotherapy Post Haploidentical Stem Cell Transplantation

Neuroblastoma (NB) is the most common solid extracranial tumor in childhood. Despite therapeutic progress, prognosis in high-risk NB is poor and innovative therapies are urgently needed. Therefore, we addressed the potential cytotoxic capacity of interleukin (IL)-activated natural killer (NK) cells...

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Detalhes bibliográficos
Publicado no:Front Immunol
Main Authors: Heinze, Annekathrin, Grebe, Beatrice, Bremm, Melanie, Huenecke, Sabine, Munir, Tasleem Ah., Graafen, Lea, Frueh, Jochen T., Merker, Michael, Rettinger, Eva, Soerensen, Jan, Klingebiel, Thomas, Bader, Peter, Ullrich, Evelyn, Cappel, Claudia
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2019
Assuntos:
Immunology
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901699/
https://ncbi.nlm.nih.gov/pubmed/31849984
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3389/fimmu.2019.02816
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