Sanguinarine inhibits epithelial–mesenchymal transition via targeting HIF-1α/TGF-β feed-forward loop in hepatocellular carcinoma

Epithelial–mesenchymal transition (EMT) plays a crucial role in hepatocellular carcinoma (HCC) progression. Hypoxia and excessive transforming growth factor-β (TGF-β) have been identified as inducers and target for EMT in HCC. Here, we show hypoxia inducible factor-1α (HIF-1α) and TGF-β form a feed-...

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Detalhes bibliográficos
Publicado no:Cell Death Dis
Main Authors: Su, Qi, Fan, Mengying, Wang, Jingjing, Ullah, Asmat, Ghauri, Mohsin Ahmad, Dai, Bingling, Zhan, Yingzhuan, Zhang, Dongdong, Zhang, Yanmin
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901539/
https://ncbi.nlm.nih.gov/pubmed/31819036
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41419-019-2173-1
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