CDR3α drives selection of the immunodominant Epstein Barr virus (EBV) BRLF1-specific CD8 T cell receptor repertoire in primary infection

The T cell receptor (TCR) repertoire is an essential component of the CD8 T-cell immune response. Here, we seek to investigate factors that drive selection of TCR repertoires specific to the HLA-A2-restricted immunodominant epitope BRLF1(109-117) (YVLDHLIVV) over the course of primary Epstein Barr v...

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Vydáno v:PLoS Pathog
Hlavní autoři: Kamga, Larisa, Gil, Anna, Song, Inyoung, Brody, Robin, Ghersi, Dario, Aslan, Nuray, Stern, Lawrence J., Selin, Liisa K., Luzuriaga, Katherine
Médium: Artigo
Jazyk:Inglês
Vydáno: Public Library of Science 2019
Témata:
Research Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901265/
https://ncbi.nlm.nih.gov/pubmed/31765434
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.ppat.1008122
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