A Phase 2 Study of Dalantercept, an Activin Receptor-Like Kinase-1 Ligand Trap, in Patients With Recurrent or Metastatic Squamous Cell Carcinoma of the Head and Neck

BACKGROUND: Patients with platinum-refractory, recurrent or metastatic squamous cell carcinoma of the head and neck (RM-SCCHN) have limited options. Activin receptor-like kinase 1 (ALK1) is a type I receptor of the transforming growth factor β superfamily expressed on activated endothelial cells. Da...

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Publicado en:Cancer
Autores principales: Jimeno, Antonio, Posner, Marshall R., Wirth, Lori J., Saba, Nabil F., Cohen, Roger B., Popa, Elizabeta C., Argiris, Athanassios, Grossmann, Kenneth F., Sukari, Ammar, Wilson, Dawn, Zhang, Xiaosha, Sun, Jade, Glasser, Chad, Attie, Kenneth M., Sherman, Matthew L., Pandya, Susan S., Weiss, Jared
Formato: Artigo
Lenguaje:Inglês
Publicado: 2016
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Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6901028/
https://ncbi.nlm.nih.gov/pubmed/27648727
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/cncr.30317
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