Inhibition of PRMT5 Attenuates Oxidative Stress-Induced Pyroptosis via Activation of the Nrf2/HO-1 Signal Pathway in a Mouse Model of Renal Ischemia-Reperfusion Injury

BACKGROUND: Extensive evidence has demonstrated that oxidative stress, pyroptosis, and proinflammatory programmed cell death are related to renal ischemia/reperfusion (I/R) injury. However, the underlying mechanism remains to be illustrated. Protein arginine methylation transferase 5 (PRMT5), which...

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Publicado en:Oxid Med Cell Longev
Autores principales: Diao, Changhui, Chen, Zhiyuan, Qiu, Tao, Liu, Hao, Yang, Yuanyuan, Liu, Xiuheng, Wu, Junfeng, Wang, Lei
Formato: Artigo
Lenguaje:Inglês
Publicado: Hindawi 2019
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899313/
https://ncbi.nlm.nih.gov/pubmed/31885778
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1155/2019/2345658
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