Loss of interleukin 10 exacerbates early type 1 diabetes-induced bone loss.

Type-1 diabetes (T1D) increases systemic inflammation, bone loss, and risk for bone fractures. Levels of the anti-inflammatory cytokine IL-10 are decreased in T1D, however their role in T1D-induced osteoporosis is unknown. To address this, diabetes was induced in male IL-10 knockout (KO) and wild-ty...

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Veröffentlicht in:J Cell Physiol
Hauptverfasser: Rios-Arce, Naiomy Deliz, Dagenais, Andrew, Feenstra, Derrick, Coughlin, Brandon, Kang, Ho Jun, Mohr, Susanne, McCabe, Laura R., Parameswaran, Narayanan
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899206/
https://ncbi.nlm.nih.gov/pubmed/31538345
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1002/jcp.29141
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