SILAC-based quantitative proteomics using mass spectrometry quantifies endoplasmic reticulum stress in whole HeLa cells

The unfolded protein response (UPR) involves extensive proteome remodeling in many cellular compartments. To date, a comprehensive analysis of the UPR has not been possible because of technological limitations. Here, we employ stable isotope labeling with amino acids in cell culture (SILAC)-based pr...

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Udgivet i:Dis Model Mech
Main Authors: Itzhak, Daniel N., Sacco, Francesca, Nagaraj, Nagarjuna, Tyanova, Stefka, Mann, Matthias, Murgia, Marta
Format: Artigo
Sprog:Inglês
Udgivet: The Company of Biologists Ltd 2019
Fag:
Resource Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899043/
https://ncbi.nlm.nih.gov/pubmed/31628211
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/dmm.040741
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