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Heterogeneous response of endothelial cells to insulin-like growth factor 1 treatment is explained by spatially clustered sub-populations

A common strategy to measure the efficacy of drug treatment is the in vitro comparison of ensemble readouts with and without treatment, such as proliferation and cell death. A fundamental assumption underlying this approach is that there exists minimal cell-to-cell variability in the response to a d...

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Detalles Bibliográficos
Publicado en:Biol Open
Main Authors: Kim, Christina, Seedorf, Gregory J., Abman, Steven H., Shepherd, Douglas P.
Formato: Artigo
Idioma:Inglês
Publicado: The Company of Biologists Ltd 2019
Assuntos:
Acceso en liña:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899026/
https://ncbi.nlm.nih.gov/pubmed/31649121
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/bio.045906
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