DDX56 inhibits type I interferon by disrupting assembly of IRF3–IPO5 to inhibit IRF3 nucleus import

Transcription factor IRF3-mediated type I interferon induction plays a role in antiviral innate immunity. However, mechanisms for the control and regulation of IRF3 nuclear import remain largely unknown. We have identified DEAD box polypeptide 56 (DDX56) as a negative regulator of virus-triggered IF...

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Detalhes bibliográficos
Publicado no:J Cell Sci
Main Authors: Li, Dan, Fu, Shaozu, Wu, Zhengqian, Yang, Wenping, Ru, Yi, Shu, Hongbing, Liu, Xiangtao, Zheng, Haixue
Formato: Artigo
Idioma:Inglês
Publicado em: The Company of Biologists Ltd 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6899003/
https://ncbi.nlm.nih.gov/pubmed/31340999
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1242/jcs.230409
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