DNA methylation of a NF-κB binding site in the aquaporin 5 promoter impacts on mortality in sepsis

Altered aquaporin 5 (AQP5) expression in immune cells impacts on key mechanisms of inflammation and is associated with sepsis survival. Since epigenetic regulation via DNA methylation might contribute to a differential AQP5 expression in sepsis, we tested the hypotheses that DNA methylation of the A...

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Detalhes bibliográficos
Publicado no:Sci Rep
Main Authors: Rump, Katharina, Unterberg, Matthias, Dahlke, Agnes, Nowak, Hartmuth, Koos, Björn, Bergmann, Lars, Siffert, Winfried, Schäfer, Simon T., Peters, Jürgen, Adamzik, Michael, Rahmel, Tim
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Publishing Group UK 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6898603/
https://ncbi.nlm.nih.gov/pubmed/31811204
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41598-019-55051-8
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