Amyloid-beta impairs insulin signaling by accelerating autophagy-lysosomal degradation of LRP-1 and IR-β in blood-brain barrier endothelial cells in vitro and in 3XTg-AD mice

Aberrant insulin signaling constitutes an early change in Alzheimer's disease (AD). Insulin receptors (IR) and low-density lipoprotein receptor-related protein-1 (LRP-1) are expressed in brain capillary endothelial cells (BCEC) forming the blood-brain barrier (BBB). There, insulin may regulate...

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Pubblicato in:Mol Cell Neurosci
Autori principali: Gali, Chaitanya Chakravarthi, Fanaee-Danesh, Elham, Zandl-Lang, Martina, Albrecher, Nicole Maria, Tam-Amersdorfer, Carmen, Stracke, Anika, Sachdev, Vinay, Reichmann, Florian, Sun, Yidan, Avdili, Afrim, Reiter, Marielies, Kratky, Dagmar, Holzer, Peter, Lass, Achim, Kandimalla, Karunya K., Panzenboeck, Ute
Natura: Artigo
Lingua:Inglês
Pubblicazione: 2019
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Article
Accesso online:https://ncbi.nlm.nih.gov/pmc/articles/PMC6897558/
https://ncbi.nlm.nih.gov/pubmed/31276749
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.mcn.2019.103390
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