Intracerebroventricular administration of the thyroid hormone analog TRIAC increases its brain content in the absence of MCT8

Patients lacking the thyroid hormone (TH) transporter MCT8 present abnormal serum levels of TH: low thyroxine and high triiodothyronine. They also have severe neurodevelopmental defects resulting from cerebral hypothyroidism, most likely due to impaired TH transport across the brain barriers. The us...

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Detaylı Bibliyografya
Yayımlandı:PLoS One
Asıl Yazarlar: Bárez-López, Soledad, Grijota-Martínez, Carmen, Liao, Xiao-Hui, Refetoff, Samuel, Guadaño-Ferraz, Ana
Materyal Türü: Artigo
Dil:Inglês
Baskı/Yayın Bilgisi: Public Library of Science 2019
Konular:
Research Article
Online Erişim:https://ncbi.nlm.nih.gov/pmc/articles/PMC6897405/
https://ncbi.nlm.nih.gov/pubmed/31809508
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pone.0226017
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