Stoichiometric Analyses of Soluble CD4 to Native-like HIV-1 Envelope by Single-Molecule Fluorescence Spectroscopy

Analyses of HIV-1 envelope (Env) binding to CD4, and the conformational changes the interactions induce, inform the molecular mechanisms and factors governing HIV-1 infection. To address these questions, we used a single-molecule detection (SMD) approach to study the nature of reactions between solu...

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Udgivet i:Cell Rep
Main Authors: Agrawal, Parul, DeVico, Anthony L., Foulke, James S., Lewis, George K., Pazgier, Marzena, Ray, Krishanu
Format: Artigo
Sprog:Inglês
Udgivet: 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6897359/
https://ncbi.nlm.nih.gov/pubmed/31577947
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1016/j.celrep.2019.08.074
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