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Simultaneously inactivating Src and AKT by saracatinib/capivasertib co-delivery nanoparticles to improve the efficacy of anti-Src therapy in head and neck squamous cell carcinoma

BACKGROUND: Src, an oncoprotein that drives progression of head and neck squamous cell carcinoma (HNSCC), is commonly hyperactivated in this disease. Unfortunately, the clinical benefit of targeting Src is significantly dampened in HNSCC patients, because the cytotoxic effects of anti-Src therapy an...

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Dades bibliogràfiques
Publicat a:J Hematol Oncol
Autors principals: Lang, Liwei, Shay, Chloe, Zhao, Xiangdong, Xiong, Yuanping, Wang, Xuli, Teng, Yong
Format: Artigo
Idioma:Inglês
Publicat: BioMed Central 2019
Matèries:
Accés en línia:https://ncbi.nlm.nih.gov/pmc/articles/PMC6896687/
https://ncbi.nlm.nih.gov/pubmed/31805962
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s13045-019-0827-1
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