Design, synthesis and molecular modelling studies of some pyrazole derivatives as carbonic anhydrase inhibitors

In this study, newly synthesised compounds 6, 8, 10 and other compounds (1–5, 7 and 9) and their inhibitory properties against the human isoforms hCA I and hCA II were reported for the first time. Compounds 1–10 showed effective inhibition profiles with K(I) values in the range of 5.13–16.9 nM for h...

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Библиографические подробности
Опубликовано в: :J Enzyme Inhib Med Chem
Главные авторы: Dizdaroglu, Yazgı, Albay, Canan, Arslan, Tayfun, Ece, Abdulilah, Turkoglu, Emir A., Efe, Asiye, Senturk, Murat, Supuran, Claudiu T., Ekinci, Deniz
Формат: Artigo
Язык:Inglês
Опубликовано: Taylor & Francis 2019
Предметы:
Research Paper
Online-ссылка:https://ncbi.nlm.nih.gov/pmc/articles/PMC6896446/
https://ncbi.nlm.nih.gov/pubmed/31797703
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/14756366.2019.1695791
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