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Efficient Gene Disruption via Base Editing Induced Stop in Newt Pleurodeles waltl
Loss-of-function approaches provide strong evidence for determining the role of particular genes. The prevalent CRISPR/Cas9 technique is widely used to disrupt target gene with uncontrolled non-homologous end joining after the double strand breaks, which results in mosaicism and multiple genotypes i...
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| Опубликовано в: : | Genes (Basel) |
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| Главные авторы: | , , , |
| Формат: | Artigo |
| Язык: | Inglês |
| Опубликовано: |
MDPI
2019
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| Предметы: | |
| Online-ссылка: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6895984/ https://ncbi.nlm.nih.gov/pubmed/31652881 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/genes10110837 |
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