Epigenetic silencing of SALL2 confers tamoxifen resistance in breast cancer

Resistance to tamoxifen is a clinically major challenge in breast cancer treatment. Although downregulation of estrogen receptor‐alpha (ERα) is the dominant mechanism of tamoxifen resistance, the reason for ERα decrease during tamoxifen therapy remains elusive. Herein, we reported that Spalt‐like tr...

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Veröffentlicht in:EMBO Mol Med
Hauptverfasser: Ye, Liping, Lin, Chuyong, Wang, Xi, Li, Qiji, Li, Yue, Wang, Meng, Zhao, Zekun, Wu, Xianqiu, Shi, Dongni, Xiao, Yunyun, Ren, Liangliang, Jian, Yunting, Yang, Meisongzhu, Ou, Ruizhang, Deng, Guangzheng, Ouyang, Ying, Chen, Xiangfu, Li, Jun, Song, Libing
Format: Artigo
Sprache:Inglês
Veröffentlicht: John Wiley and Sons Inc. 2019
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Articles
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895605/
https://ncbi.nlm.nih.gov/pubmed/31657150
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.15252/emmm.201910638
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