Akt inhibition at the initial stage of CAR-T preparation enhances the CAR-positive expression rate, memory phenotype and in vivo efficacy

The adoptive transfer of chimeric antigen receptor-modified T (CAR-T) cells is a novel cancer treatment that has led to encouraging breakthroughs in the treatment of haematological malignancies. The efficacy of infused CAR-T cells is associated with a high CAR-positive expression rate, a strong prol...

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Vydáno v:Am J Cancer Res
Hlavní autoři: Zhang, Qing, Ding, Jiage, Sun, Shishuo, Liu, Hongyan, Lu, Mengmeng, Wei, Xiaohuan, Gao, Xiaoge, Zhang, Xiaokang, Fu, Qiang, Zheng, Junnian
Médium: Artigo
Jazyk:Inglês
Vydáno: e-Century Publishing Corporation 2019
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Original Article
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895454/
https://ncbi.nlm.nih.gov/pubmed/31815041
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