Ellagic acid reduces methotrexate-induced apoptosis and mitochondrial dysfunction via up-regulating Nrf2 expression and inhibiting the IĸBα/NFĸB in rats

BACKGROUND: The clinical application of methotrexate (MTX), an efficacious cytotoxic drug, is restricted due to its associated liver toxicity. Ellagic acid (EA), a natural polyphenol, possesses hepatoprotective, antioxidant and anti-inflammatory properties. OBJECTIVES: The present study seeks to add...

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Publicado en:Daru
Autores principales: Ebrahimi, Reihaneh, Sepand, Mohammad Reza, Seyednejad, Seyed Afshin, Omidi, Ameneh, Akbariani, Mostafa, Gholami, Maryam, Sabzevari, Omid
Formato: Artigo
Lenguaje:Inglês
Publicado: Springer International Publishing 2019
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Research Article
Acceso en línea:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895372/
https://ncbi.nlm.nih.gov/pubmed/31736017
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40199-019-00309-9
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