Metformin-induced AMPK activation stimulates remyelination through induction of neurotrophic factors, downregulation of NogoA and recruitment of Olig2+ precursor cells in the cuprizone murine model of multiple sclerosis

PURPOSE: Oligodendrocytes (OLGs) damage and myelin distraction is considered as a critical step in many neurological disorders especially multiple sclerosis (MS). Cuprizone (cup) animal model of MS targets OLGs degeneration and frequently used to the mechanistic understanding of de- and remyelinatio...

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Detalhes bibliográficos
Publicado no:Daru
Main Authors: Houshmand, Fariba, Barati, Mahmood, Golab, Fereshteh, Ramezani-sefidar, Samaneh, Tanbakooie, Sara, Tabatabaei, Mahsa, Amiri, Masoomeh, Sanadgol, Nima
Formato: Artigo
Idioma:Inglês
Publicado em: Springer International Publishing 2019
Assuntos:
Research Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895294/
https://ncbi.nlm.nih.gov/pubmed/31620963
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1007/s40199-019-00286-z
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