Conformational pathway provides unique sensitivity to a synaptic mGluR

Metabotropic glutamate receptors (mGluRs) are dimeric G-protein–coupled receptors that operate at synapses. Macroscopic and single molecule FRET to monitor structural rearrangements in the ligand binding domain (LBD) of the mGluR7/7 homodimer revealed it to have an apparent affinity ~4000-fold lower...

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Udgivet i:Nat Commun
Main Authors: Habrian, Chris H., Levitz, Joshua, Vyklicky, Vojtech, Fu, Zhu, Hoagland, Adam, McCort-Tranchepain, Isabelle, Acher, Francine, Isacoff, Ehud Y.
Format: Artigo
Sprog:Inglês
Udgivet: Nature Publishing Group UK 2019
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Article
Online adgang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6895203/
https://ncbi.nlm.nih.gov/pubmed/31804469
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41467-019-13407-8
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