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Local vulnerability and global connectivity jointly shape neurodegenerative disease propagation

It is becoming increasingly clear that brain network organization shapes the course and expression of neurodegenerative diseases. Parkinson disease (PD) is marked by progressive spread of atrophy from the midbrain to subcortical structures and, eventually, to the cerebral cortex. Recent discoveries...

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Detalhes bibliográficos
Publicado no:PLoS Biol
Main Authors: Zheng, Ying-Qiu, Zhang, Yu, Yau, Yvonne, Zeighami, Yashar, Larcher, Kevin, Misic, Bratislav, Dagher, Alain
Formato: Artigo
Idioma:Inglês
Publicado em: Public Library of Science 2019
Assuntos:
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6894889/
https://ncbi.nlm.nih.gov/pubmed/31751329
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1371/journal.pbio.3000495
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