Human induced pluripotent stem cells from two azoospermic patients with Klinefelter syndrome show similar X chromosome inactivation behavior to female pluripotent stem cells

STUDY QUESTION: Does the X chromosome inactivation (XCI) of Klinefelter syndrome (KS)-derived human induced pluripotent stem cells (hiPSCs) correspond to female human pluripotent stem cells (hPSCs) and reflect the KS genotype? SUMMARY ANSWER: Our results demonstrate for the first time that KS-derive...

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Detalhes bibliográficos
Publicado no:Hum Reprod
Main Authors: Panula, Sarita, Kurek, Magdalena, Kumar, Pankaj, Albalushi, Halima, Padrell Sánchez, Sara, Damdimopoulou, Pauliina, Olofsson, Jan I, Hovatta, Outi, Lanner, Fredrik, Stukenborg, Jan-Bernd
Formato: Artigo
Idioma:Inglês
Publicado em: Oxford University Press 2019
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Original Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6894010/
https://ncbi.nlm.nih.gov/pubmed/31743397
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1093/humrep/dez134
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