Regulation of Lifespan by Neural Excitation and REST

The mechanisms that extend lifespan in humans are poorly understood. Here we show that extended longevity in humans is associated with a distinct transcriptome signature in the cerebral cortex characterized by downregulation of genes related to neural excitation and synaptic function. In the model s...

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Detalhes bibliográficos
Publicado no:Nature
Main Authors: Zullo, Joseph M., Drake, Derek, Aron, Liviu, O’Hern, Patrick, Dhamne, Sameer C., Davidsohn, Noah, Mao, Chai-An, Klein, William H., Rotenberg, Alexander, Bennett, David A., Church, George M., Colaiácovo, Monica P., Yankner, Bruce A.
Formato: Artigo
Idioma:Inglês
Publicado em: 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6893853/
https://ncbi.nlm.nih.gov/pubmed/31619788
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1038/s41586-019-1647-8
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