Pathway-Based High-Throughput Chemical Screen Identifies Compounds That Decouple Heterochromatin Transformations

Heterochromatin protein 1 (HP1) facilitates the formation of repressive heterochromatin domains by recruiting histone lysine methyltransferase enzymes to chromatin, resulting in increased levels of histone H3K9me3. To identify chemical inhibitors of the HP1-heterochromatin gene repression pathway, w...

पूर्ण विवरण

में बचाया:
ग्रंथसूची विवरण
में प्रकाशित:SLAS Discov
मुख्य लेखकों: MacDonald, Ian A., Butler, Kyle V., Herring, Laura E., Clinkscales, Sarah E., Yelagandula, Ramesh, Stecher, Karin, Bell, Oliver, Graves, Lee M., Jin, Jian, Hathaway, Nathaniel A.
स्वरूप: Artigo
भाषा:Inglês
प्रकाशित: 2019
विषय:
Article
ऑनलाइन पहुंच:https://ncbi.nlm.nih.gov/pmc/articles/PMC6893849/
https://ncbi.nlm.nih.gov/pubmed/31145866
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555219849838
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