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Pathway-Based High-Throughput Chemical Screen Identifies Compounds That Decouple Heterochromatin Transformations
Heterochromatin protein 1 (HP1) facilitates the formation of repressive heterochromatin domains by recruiting histone lysine methyltransferase enzymes to chromatin, resulting in increased levels of histone H3K9me3. To identify chemical inhibitors of the HP1-heterochromatin gene repression pathway, w...
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| Publicado en: | SLAS Discov |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
2019
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| Assuntos: | |
| Acceso en liña: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6893849/ https://ncbi.nlm.nih.gov/pubmed/31145866 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1177/2472555219849838 |
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