Adenylyl Cyclase Type 8 Overexpression Impairs Phosphorylation-Dependent Orai1 Inactivation and Promotes Migration in MDA-MB-231 Breast Cancer Cells

Orai1 plays a major role in store-operated Ca(2+) entry (SOCE) in triple-negative breast cancer (TNBC) cells. This channel is inactivated via different mechanisms, including protein kinase C (PKC) and protein kinase A (PKA)-dependent phosphorylation at Ser-27 and Ser-30 or Ser-34, respectively, whic...

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Detalhes bibliográficos
Publicado no:Cancers (Basel)
Main Authors: Sanchez-Collado, Jose, Lopez, Jose J., Jardin, Isaac, Camello, Pedro J., Falcon, Debora, Regodon, Sergio, Salido, Gines M., Smani, Tarik, Rosado, Juan A.
Formato: Artigo
Idioma:Inglês
Publicado em: MDPI 2019
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Article
Acesso em linha:https://ncbi.nlm.nih.gov/pmc/articles/PMC6893434/
https://ncbi.nlm.nih.gov/pubmed/31652779
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.3390/cancers11111624
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