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Comprehensive Scanning Mutagenesis of Human Retrotransposon LINE-1 Identifies Motifs Essential for Function
Long Interspersed Nuclear Element-1 (LINE-1, L1) is the only autonomous active transposable element in the human genome. The L1-encoded proteins ORF1p and ORF2p enable the element to jump from one locus to another via a “copy-and-paste” mechanism. ORF1p is an RNA-binding protein, and ORF2p has endon...
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| Publicado no: | Genetics |
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| Main Authors: | , , , , , , , , , |
| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado em: |
Genetics Society of America
2019
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| Assuntos: | |
| Acesso em linha: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6893370/ https://ncbi.nlm.nih.gov/pubmed/31666291 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1534/genetics.119.302601 |
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