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Enhancing Retinal Endothelial Glycolysis by Inhibiting UCP2 Promotes Physiologic Retinal Vascular Development in a Model of Retinopathy of Prematurity
PURPOSE: We address the hypothesis that uncoupling protein 2 (UCP2), a cellular glucose regulator, delays physiologic retinal vascular development (PRVD) by interfering with glucose uptake through glucose transporter 1 (Glut1). METHODS: In the rat 50/10 oxygen-induced retinopathy (OIR) model, retina...
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| Publicado en: | Invest Ophthalmol Vis Sci |
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| Autores principales: | , , , |
| Formato: | Artigo |
| Lenguaje: | Inglês |
| Publicado: |
The Association for Research in Vision and Ophthalmology
2019
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| Materias: | |
| Acceso en línea: | https://ncbi.nlm.nih.gov/pmc/articles/PMC6892377/ https://ncbi.nlm.nih.gov/pubmed/30995317 https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1167/iovs.19-26553 |
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