Potential factors contributing to the poor antimicrobial efficacy of SAAP-148 in a rat wound infection model

BACKGROUND: We investigated the efficacy of a synthetic antimicrobial peptide SAAP-148, which was shown to be effective against Methicillin-resistant Staphylococcus aureus (MRSA) on tape-stripped mice skin. Unexpectedly, SAAP-148 was not effective against MRSA in our pilot study using rats with exci...

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Vydáno v:Ann Clin Microbiol Antimicrob
Hlavní autoři: Dijksteel, Gabrielle S., Ulrich, Magda M. W., Vlig, Marcel, Nibbering, Peter H., Cordfunke, Robert A., Drijfhout, Jan W., Middelkoop, Esther, Boekema, Bouke K. H. L.
Médium: Artigo
Jazyk:Inglês
Vydáno: BioMed Central 2019
Témata:
Research
On-line přístup:https://ncbi.nlm.nih.gov/pmc/articles/PMC6891976/
https://ncbi.nlm.nih.gov/pubmed/31796055
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1186/s12941-019-0336-7
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