Prostate tumor cell-derived IL-1β induces an inflammatory phenotype in bone marrow adipocytes and reduces sensitivity to docetaxel via lipolysis-dependent mechanisms

Adipocyte-tumor cell crosstalk is one of the critical mediators of tumor progression and an emerging facilitator of therapy evasion. Tumor cells that metastasize to adipocyte-rich bone marrow take advantage of the interplay between metabolic and inflammatory pathways to activate pro-survival mechani...

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Veröffentlicht in:Mol Cancer Res
Hauptverfasser: Herroon, Mackenzie K, Diedrich, Jonathan D, Rajagurubandara, Erandi, Martin, Carly, Maddipati, Krishnarao, Kim, Seongho, Heath, Elisabeth I, Granneman, James, Podgorski, Izabela
Format: Artigo
Sprache:Inglês
Veröffentlicht: 2019
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Article
Online Zugang:https://ncbi.nlm.nih.gov/pmc/articles/PMC6891205/
https://ncbi.nlm.nih.gov/pubmed/31562254
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1158/1541-7786.MCR-19-0540
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