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Evidence for altered excitatory and inhibitory tone in the postmortem substantia nigra in schizophrenia

OBJECTIVES: The substantia nigra (SN) receives glutamatergic and GABAergic inputs that regulate dopaminergic neuronal activity. Imaging studies have shown hyperactivity of the SN in schizophrenia (SZ) patients. We examined neurochemically-defined inputs to the SN, synaptic density, and neuromelanin...

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Détails bibliographiques
Publié dans:World J Biol Psychiatry
Auteurs principaux: Mabry, Samuel J., McCollum, Lesley A., Farmer, Charlene B., Bloom, Emma S., Roberts, Rosalinda C.
Format: Artigo
Langue:Inglês
Publié: 2019
Sujets:
Accès en ligne:https://ncbi.nlm.nih.gov/pmc/articles/PMC6891153/
https://ncbi.nlm.nih.gov/pubmed/31062628
https://ncbi.nlm.nih.govhttp://dx.doi.org/10.1080/15622975.2019.1615638
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